Phactr2 and Parkinson's disease
Identifieur interne : 002070 ( Main/Exploration ); précédent : 002069; suivant : 002071Phactr2 and Parkinson's disease
Auteurs : Christian Wider [États-Unis] ; Sarah J. Lincoln [États-Unis] ; Michael G. Heckman [États-Unis] ; Nancy N. Diehl [États-Unis] ; Jeremy T. Stone [États-Unis] ; Kristoffer Haugarvoll [États-Unis, Norvège] ; Jan O. Aasly [Norvège] ; J. Mark Gibson [Irlande (pays)] ; Timothy Lynch [Irlande (pays)] ; Alex Rajput [Canada] ; Michele L. Rajput [Canada] ; Ryan J. Uitti [États-Unis] ; Zbigniew K. Wszolek [États-Unis] ; Matthew J. Farrer [États-Unis] ; Owen A. Ross [États-Unis]Source :
- Neuroscience letters [ 0304-3940 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P=0.032), Canadian (OR: 1.41, P= 0.014) and Irish (OR: 1.44, P=0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P=0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P< 0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.
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Mark Gibson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Royal Victoria Hospital</s1><s2>Belfast</s2><s3>IRL</s3><sZ>8 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Dublin Neurological Institute, Mater Misericordiae Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>University College Dublin Conway Neuroscience Investigator</s1><s2>Dublin</s2><s3>IRL</s3><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>University College Dublin Conway Neuroscience Investigator</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Neurology, University of Saskatchewan and Saskatoon Health Region</s1><s2>Saskatoon, Saskatchewan</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon, Saskatchewan</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Saskatchewan Center for Parkinson's disease and Movement Disorders, Royal University Hospital</s1><s2>Saskatoon, Saskatchewan</s2><s3>CAN</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon, Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Michele L" sort="Rajput, Michele L" uniqKey="Rajput M" first="Michele L." last="Rajput">Michele L. 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Ross</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0257703</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0257703 INIST</idno><idno type="RBID">Pascal:09-0257703</idno><idno type="wicri:Area/PascalFrancis/Corpus">000544</idno><idno type="wicri:Area/PascalFrancis/Curation">000748</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000424</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000424</idno><idno type="wicri:doubleKey">0304-3940:2009:Wider C:phactr:and:parkinson</idno><idno type="wicri:Area/Main/Merge">002228</idno><idno type="wicri:Area/Main/Curation">002070</idno><idno type="wicri:Area/Main/Exploration">002070</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Phactr2 and Parkinson's disease</title><author><name sortKey="Wider, Christian" sort="Wider, Christian" uniqKey="Wider C" first="Christian" last="Wider">Christian Wider</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J." last="Lincoln">Sarah J. Lincoln</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G." last="Heckman">Michael G. Heckman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Stone, Jeremy T" sort="Stone, Jeremy T" uniqKey="Stone J" first="Jeremy T." last="Stone">Jeremy T. Stone</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Haugarvoll, Kristoffer" sort="Haugarvoll, Kristoffer" uniqKey="Haugarvoll K" first="Kristoffer" last="Haugarvoll">Kristoffer Haugarvoll</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neuroscience, Norwegian University of Science and Technology</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Neuroscience, Norwegian University of Science and Technology</s1><s2>Trondheim</s2><s3>NOR</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Trondheim</settlement><region type="région" nuts="2">Trøndelag</region></placeName></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Royal Victoria Hospital</s1><s2>Belfast</s2><s3>IRL</s3><sZ>8 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Dublin Neurological Institute, Mater Misericordiae Hospital</s1><s2>Dublin</s2><s3>IRL</s3><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Dublin</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>University College Dublin Conway Neuroscience Investigator</s1><s2>Dublin</s2><s3>IRL</s3><sZ>9 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>University College Dublin Conway Neuroscience Investigator</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Neurology, University of Saskatchewan and Saskatoon Health Region</s1><s2>Saskatoon, Saskatchewan</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon, Saskatchewan</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Saskatchewan Center for Parkinson's disease and Movement Disorders, Royal University Hospital</s1><s2>Saskatoon, Saskatchewan</s2><s3>CAN</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon, Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Michele L" sort="Rajput, Michele L" uniqKey="Rajput M" first="Michele L." last="Rajput">Michele L. Rajput</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Saskatchewan Center for Parkinson's disease and Movement Disorders, Royal University Hospital</s1><s2>Saskatoon, Saskatchewan</s2><s3>CAN</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Saskatoon, Saskatchewan</wicri:noRegion></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>12 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscience, Mayo Clinic</s1><s2>Jacksonville, FL</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Jacksonville, FL</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neuroscience letters</title><title level="j" type="abbreviated">Neurosci. lett.</title><idno type="ISSN">0304-3940</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroscience letters</title><title level="j" type="abbreviated">Neurosci. lett.</title><idno type="ISSN">0304-3940</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Attempts at replicating the first genome-wide association study (GWAS) in Parkinson's disease (PD) have not successfully identified genetic risk factors. The present study reevaluates data from the first GWAS and focuses on the SNP (rs11155313, located in the Phactr2 gene) with the lowest P-value in the Tier 2 patient-control series. We employed four case-control series to examine the nominated SNP rs11155313 and identified association in US (OR: 1.39, P<sub>=</sub>0.032), Canadian (OR: 1.41, P<sub>=</sub> 0.014) and Irish (OR: 1.44, P=0.034) patient-control series, but not in the Norwegian series (OR: 1.15, P=0.27). When combining all four series the observed trend was statistically significant (OR: 1.30, P< 0.001). This study shows that reappraisal of publicly available results of GWAS may help nominate new risk factors for PD.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Irlande (pays)</li><li>Norvège</li><li>États-Unis</li></country><region><li>Trøndelag</li></region><settlement><li>Trondheim</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Wider, Christian" sort="Wider, Christian" uniqKey="Wider C" first="Christian" last="Wider">Christian Wider</name></noRegion><name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><name sortKey="Haugarvoll, Kristoffer" sort="Haugarvoll, Kristoffer" uniqKey="Haugarvoll K" first="Kristoffer" last="Haugarvoll">Kristoffer Haugarvoll</name><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G." last="Heckman">Michael G. Heckman</name><name sortKey="Lincoln, Sarah J" sort="Lincoln, Sarah J" uniqKey="Lincoln S" first="Sarah J." last="Lincoln">Sarah J. Lincoln</name><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><name sortKey="Stone, Jeremy T" sort="Stone, Jeremy T" uniqKey="Stone J" first="Jeremy T." last="Stone">Jeremy T. Stone</name><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name></country><country name="Norvège"><region name="Trøndelag"><name sortKey="Haugarvoll, Kristoffer" sort="Haugarvoll, Kristoffer" uniqKey="Haugarvoll K" first="Kristoffer" last="Haugarvoll">Kristoffer Haugarvoll</name></region><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name></noRegion><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name></country><country name="Canada"><noRegion><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name></noRegion><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><name sortKey="Rajput, Michele L" sort="Rajput, Michele L" uniqKey="Rajput M" first="Michele L." last="Rajput">Michele L. Rajput</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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